Evaluation of the enrofloxacin excretion in Anatolian buffalo milk

Enrofloxacin (ENR) is a broad-spectrum fluoroquinolone antibiotic widely used in both human medicine and veterinary medicine. In this study, the milk-excretion patterns of ENR its metabolite ciprofloxacin (CIP) were determined up to 10th milking following intramuscular administration (2.5mg/kg body weight) lactating dairy buffaloes. The milk each animal was collected concentrations CIP detected by LC-MS/MS. detection limits method for as 0.35 μg/kg 0.12 μg/kg, respectively. highest total mean second after injection 603 μg/kg. residue level all buffalo samples found be lower than maximum limit (100 μg/kg) at fifth milking. addition, employed successfully applied evaluate presence 50 marketed none contained these antibiotics. Consequently, present study provided information on excretion levels Anatolian milks an LC-MS/MS method.